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Inhibition of Human Cytochrome P450 Enzymes by 1,2-Dithiole-3-thione, Oltipraz and Its Derivatives, and Sulforaphane

✍ Scribed by Langouët, Sophie; Furge, Laura Lowe; Kerriguy, Nathalie; Nakamura, Katsunori; Guillouzo, André; Guengerich, F. Peter


Book ID
121459851
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
95 KB
Volume
13
Category
Article
ISSN
0893-228X

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## Abstract The inhibitory effects of flavonoids on the human cytochrome P450 1A2 (CYP1A2) were examined. Among flavonoids tested, galangin, kaempferol, chrysin, and apigenin were potent inhibitors. Although apigenin belonging to flavones and genistein belonging to isoflavones are similar in the ch