Inhibition of human breast cancer Matrigel invasion by Streptolysin O activation of the EGF receptor ErbB1
β Scribed by Emily H. Hall; Volkan Gurel; Albert E. Dahlberg; John McMichael; David L. Brautigan
- Book ID
- 113528565
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 973 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0898-6568
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract It was shown previously that Ea4βpeptide of trout proβIGFβI exerted mitogenic activity in nonβtransformed cells and inhibited colony formation in a soft agar medium of established human cancer cells. Here we report that the same peptide inhibits the invasion of human breast cancer cells
Transforming growth factor-beta (TGFβ€1) enhances human MDA-MB-231 breast tumour cell invasion of reconstituted basement membrane in vitro but does not inhibit proliferation of this cell line. In contrast to basal invasion, which is plasmin-, urokinase (uPA)-, tissue-type plasminogen activator (t-PA)