✦ LIBER ✦

Inhibition of histone deacetylase as a new mechanism of teratogenesis

✍ Scribed by Elena Menegola; Francesca Di Renzo; Maria Luisa Broccia; Erminio Giavini

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 321 KB
Volume: 78
Category: Article
ISSN: 1542-975X
DOI: 10.1002/bdrc.20082

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Inhibition of histone deacetylase activi

Inhibition of histone deacetylase activity on specific embryonic tissues as a new mechanism for teratogenicity

✍ Elena Menegola; Francesca Di Renzo; Maria L. Broccia; Michela Prudenziati; Saver 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 248 KB 👁 1 views

## Background: The inhibition of histone deacetylase (hdac) has been reported as an effective mechanism on therapy in neoplastic diseases. among hdac inhibitors, trichostatin a (tsa) and valproic acid (vpa) prevent the tumorigenesis in rodent and human models. malformations as neural tube and axial

Oxidative stress as a mechanism of terat

Oxidative stress as a mechanism of teratogenesis

✍ Jason M. Hansen 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 361 KB

Discovery of Pyrimidyl-5-hydroxamic Acid

Discovery of Pyrimidyl-5-hydroxamic Acids as New Potent Histone Deacetylase Inhibitors.

✍ Patrick Angibaud; et al. et al. 📂 Article 📅 2005 🏛 John Wiley and Sons ⚖ 24 KB 👁 1 views

Histone deacetylase inhibitors: Understa

Histone deacetylase inhibitors: Understanding a new wave of anticancer agents

✍ Ana Villar-Garea; Manel Esteller 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 346 KB

## Abstract Cancer is as much an epigenetic disease as it is a genetic and cytogenetic disease. The discovery that drastic changes in DNA methylation and histone modifications are commonly found in human tumors has inspired various laboratories and pharmaceutical companies to develop and study epig

Enhancing the antitumor activity of ErbB

Enhancing the antitumor activity of ErbB blockade with histone deacetylase (HDAC) inhibition

✍ Prakash Chinnaiyan; Sooryanarayana Varambally; Scott A. Tomlins; Soma Ray; Shyhm 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 332 KB

## Abstract Molecular inhibition of the ErbB signaling pathway represents a promising cancer treatment strategy. Preclinical studies suggest that enhancement of antitumor activity can be achieved by maximizing ErbB signaling inhibition. Using cDNA microarrays, we identified histone deacetylase (HDA

Succinimide Hydroxamic Acids as Potent I

Succinimide Hydroxamic Acids as Potent Inhibitors of Histone Deacetylase (HDAC).

✍ Michael L. Curtin; Robert B. Garland; H. Robin Heyman; Robin R. Frey; Michael R. 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 135 KB 👁 2 views