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Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation

✍ Scribed by Yingli Sun; Xiaofeng Jiang; Shujuan Chen; Brendan D. Price

Book ID: 116466836
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 174 KB
Volume: 580
Category: Article
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2006.06.092

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## Abstract Oleanolic acid (OA), a pentacyclic triterpenoid exhibits potent anti‐tumor activity against many tumor cell lines. But the mechanisms through which OA inhibits osteosarcoma cells are not known. The mammalian target of rapamycin (mTOR) serves as a central regulator of cell growth, prolif