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Inhibition of histamine-N-methyltransferase activity by neuromuscular blocking drugs

✍ Scribed by D. G. Harle; B. A. Baldo; M. M. Fisher

Publisher
SP Birkhäuser Verlag Basel
Year
1985
Tongue
English
Weight
357 KB
Volume
17
Category
Article
ISSN
1420-908X

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Stereoselective inhibition by chloroquin
Stereoselective inhibition by chloroquine of histamine N-methyltransferase in the human liver and brain
✍ P. Donatelli; G. Marchi; G. M. Pacifici; L. Giuliani; L. L. Gustafsson 📂 Article 📅 1994 🏛 Springer 🌐 English ⚖ 421 KB

This study was designed to determine whether both enantiomers of chloroquine inhibit histamine N-methyltransferase. The mean estimates of ICs0 for the d-and/-enantiomers of chloroquine were 4.9 and 17.8 ~tM (liver), respectively and 6.9 and 21.6 ~tM (brain), respectively. K i estimates were signific