Inhibition of Histamine-induced Contraction of Rat Ileum by Promethazine and the Methanol Stembark Extract of Erythrina sigmoidea (Hua)

✍ Scribed by B. Nkeh; A. Kamany; M. Bopelet; J. F. Ayafor; J. T. Mbafor

• Book ID: 101286452
• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 224 KB
• Volume: 10
• Category: Article
• ISSN: 0951-418X
• DOI: 10.1002/(sici)1099-1573(199608)10:5<444::aid-ptr868>3.0.co;2-y

✦ Synopsis

Histamine, a potent HI and H, receptor agonist provoked dose dependent contractions of the rat ileal strip. The contractile effect was reduced by almost 54.6% when challenged with 1.8 pg/mL of the stembark extract of Eryfhrina sigrnoidea (ES) while 4.8 p g h L of the plant extract completely abolished M histamine-induced contraction. A similar relaxant effect was obtained with 0.5 pg/mL promethazine, a potent HI blocker, but this relaxant effect was less significant compared with that of the plant extract.