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Inhibition of hippocampal cell proliferation by methotrexate in rats is not potentiated by the presence of a tumor

✍ Scribed by Riejanne Seigers; Line Pourtau; Sanne B. Schagen; Frits S.A.M. van Dam; Jaap M. Koolhaas; Jan Pieter Konsman; Bauke Buwalda

Book ID
116327021
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
344 KB
Volume
81
Category
Article
ISSN
0361-9230

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## Abstract ## Background Inhibition of tumor angiogenesis is a promising approach for cancer therapy and the Tie‐2/angiopoietin pathway appears to play an important role. In the present study, we have developed strategies to explore the therapeutic potential of blocking the Tie‐2/angiopoietin pat