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Inhibition of High-Affinity Choline Uptake and Acetylcholine Synthesis by Quinuclidinyl and Hemicholinium Derivatives

✍ Scribed by Gerald H. Sterling; Peter H. Doukas; Fiori J. Ricciardi Jr.; Diane W. Biedrzycka; John J. O'Neill


Book ID
111173616
Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
600 KB
Volume
46
Category
Article
ISSN
0022-3042

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Previous studies have shown that NMDA evokes a calcium-dependent and region-specific increase in extracellular choline that is associated with a reduction of membrane phosphatidylcholine and precedes neuronal cell death. We investigated, using in vivo microdialysis, the contribution of high-affinity