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Inhibition of HER1 signaling pathway enhances antitumor effect of endocrine therapy in breast cancer

✍ Scribed by Junichi Kurebayashi; Sumiko Okubo; Yutaka Yamamoto; Hiroshi Sonoo


Publisher
Springer Japan
Year
2004
Tongue
English
Weight
363 KB
Volume
11
Category
Article
ISSN
1340-6868

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## Abstract We sought to determine whether seliciclib (CYC202, R‐roscovitine) could increase the antitumor effects of doxorubicin, with no increase in toxicity, in an MCF7 breast cancer xenograft model. The efficacy of seliciclib combined with doxorubicin was compared with single agent doxorubicin