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Inhibition of hepatoma-immune lymph-node cell cytotoxicity by tumour-bearer serum, and solubilized hepatoma antigen

✍ Scribed by R. W. Baldwin; M. R. Price; R. A. Robins

Publisher
John Wiley and Sons
Year
1973
Tongue
French
Weight
663 KB
Volume
11
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Sera from rats bearing transplanted aminoazo‐dye‐induced hepatomas inhibited the cytotoxicity of lymph‐node cells from tumour‐immune rats for plated hepatoma cells, when the sera were incubated with the effector cells, rather than target cells. In contrast, sera from hepatoma‐immune rats, which have previously been shown to block lymphocyte cytotoxicity at the level of the target cell, failed to inhibit lymph‐node cell cytotoxicity when pre‐incubated with the effector cells. The possibility that antigenic determinants could be responsible for lymphocyte inhibition is supported by the demonstration that papain‐solubilized hepatoma‐specific antigen preparations inhibited lymph‐node cell cytotoxicity. The role of specific antibody, antigen and immune complexes in the interaction between cellular immunity and humoral factors during tumour growth is discussed.

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