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Inhibition of hepatitis C virus RNA translation with antisense RNA expressing adenoviruses in HEPG2-cells

โœ Scribed by M.A. Gonzalez-Carmona; T. Heinicke; P. Hoffman; M. Quasdorff; T. Sauerbruch; W.H. Caselmann


Book ID
117372540
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
164 KB
Volume
38
Category
Article
ISSN
0168-8278

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We developed approaches using antisense RNA to inhibit hepatitis C virus (HCV) RNA translation and HCV core protein expression. An HCV genotype 1b cDNA comprising nt 1-1321 or a fusion construct consisting of HCV (nt 1-584) and luciferase cDNAs were inserted downstream of T7 and CMV promoter sequenc