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Inhibition of Hepatitis C IRES-Mediated Gene Expression by Small Hairpin RNAs in Human Hepatocytes and Mice

✍ Scribed by HEINI ILVES; ROGER L. KASPAR; QIAN WANG; ATTILA A. SEYHAN; ALEXANDER V. VLASSOV; CHRISTOPHER H. CONTAG; DEVIN LEAKE; BRIAN H. JOHNSTON


Book ID
111479410
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
102 KB
Volume
1082
Category
Article
ISSN
0890-6564

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## Abstract In order to develop a gene therapy to human cytomegalovirus (HCMV), RNA interference (RNAi) was employed to inhibit the expression of HCMV UL122 gene __in vitro__. Recombinant vector pUL122‐EGFP, which expressed UL122‐EGFP fusion protein, and recombinant vectors psi122‐1, psi122‐2 and p