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Inhibition of hepatitis B virus replication by adenine arabinoside monophosphate coupled to lactosaminated albumin. Efficacy and minimal active dose

โœ Scribed by M.R. Torrani Cerenzia; L. Fiume; C. Busi; A. Mattioli; G. Di Stefano; G.B. Gervasi; M.R. Brunetto; P. Piantino; G. Verme; F. Bonino

Book ID
118566129
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
222 KB
Volume
20
Category
Article
ISSN
0168-8278

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Inhibition of woodchuck hepatitis virus
Inhibition of woodchuck hepatitis virus replication by adenine arabinoside monophosphate coupled to lactosaminated poly-L-lysine and administered by intramuscular route
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We prepared a hepatotropic conjugate, suitable for intramuscular (IM) injection, of lactosaminated poly-Llysine with adenine arabinoside monophosphate (ara-AMP), a drug active against hepatitis B virus (HBW. We studied its organ distribution in mice and its antiviral activity in woodchucks that are

Adenine arabinoside monophosphate and ac
Adenine arabinoside monophosphate and acyclovir monophosphate coupled to lactosaminated albumin reduce woodchuck hepatitis virus viremia at doses lower than do the unconjugated drugs
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The woodchuck was selected to study the efficacy of liver-targeted antiviral drugs on hepadnavirus replication. Nineteen woodchucks chronically infected with woodchuck hepatitis virus were treated with adenine arabinoside monophosphate or acyclovir monophosphate, either free or conjugated with the l