Inhibition of Head and Neck Tumor Cell Growth With Arachidonic Acid Metabolism Inhibition
β Scribed by Frank G. Ondrey; Steven K. Juhn; George L. Adams
- Book ID
- 119770771
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 605 KB
- Volume
- 106
- Category
- Article
- ISSN
- 0023-852X
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The effects of retinoic acid (RA) on multicellular tumor spheroids (MTS) derived from a head and neck squamous carcinoma cell line, MDA 886Ln, were studied. Growth of MTSs was shown to be inhibited by to lo-' M RA; dose response studies demonstrated that by lo-'' M RA, MTS growth was inhibited by le
## Abstract Aberrant arachidonic acid (AA) metabolism has been involved in inflammation and carcinogenesis. The key enzymes in AA metabolism such as cytosolic phospholipase A2 (cPLA~2~) and cyclooxygenaseβ2 (COXβ2) have been implicated in the development and progression of many human cancers, inclu