Inhibition of haematogenous metastasis of colon cancer in mice by a selective COX-2 inhibitor, JTE-522
β Scribed by Tomozawa, S; Nagawa, H; Tsuno, N; Hatano, K; Osada, T; Kitayama, J; Sunami, E; Nita, M E; Ishihara, S; Yano, H
- Book ID
- 110002633
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 165 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0007-0920
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## Abstract The lung is a frequent site of metastasis from colorectal cancer, but angiogenesis of lung metastases has not been clarified. Some COXβ2 inhibitors prevent tumor growth, although the inhibitory mechanism at the metastatic site is obscure. We investigated the microvascular structure of s
## Abstract We have previously demonstrated that JTEβ522, a selective cyclooxygenaseβ2 (COXβ2) inhibitor, inhibited development of aberrant crypt foci (ACF) in rats, a putative preneoplastic lesion in colon, and suggested its inhibitory potential in rat colon carcinogenesis. To evaluate the chemopr