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Inhibition of H-Y cell-mediated cytolysis by monoclonal H-Y-specific antibody

✍ Scribed by Gloria C. Koo; Alana Varano

Book ID
104731016
Publisher
Springer-Verlag
Year
1981
Tongue
English
Weight
303 KB
Volume
14
Category
Article
ISSN
0093-7711

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✦ Synopsis

Assays of H-Y specific, cell-mediated cytolysis (CMC) in vitro were carried out with B6 female effector cells and B6 male target cells. Monoclonal H-Y antibody was added to the lytic assay to test whether the antigenic determinant(s) involved in H-Y-specific CMC was distinct from the serologically detected H-Y antigen. Significant blocking was observed, suggesting that the H-Y antigen detectable serologically is similar to H-Y antigen recognized by cytotoxic T cells.

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