Inhibition of growth of human malignant glioblastoma in nude mice by antagonists of bombesin/gastrin-releasing peptide
β Scribed by Kiaris, H; Schally, A V; Sun, B; Armatis, P; Groot, K
- Book ID
- 110062575
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 250 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0950-9232
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## Abstract Nude mice bearing xenografts of the gastrinβresponsive human gastric carcinoma MKN45 cell line were treated for 4 to 5 weeks with bombesin/gastrinβreleasingβpeptide(GRP) antagonist (RCβ3095), somatostatin analogues RCβ160 and SMS 201β995, or the combination of RCβ3095 and RCβ160. Tumor
## Abstract We investigated the effects of bombesin/GRP antagonists RCβ3095 and RCβ3940βII on the growth of SWβ1990 human pancreatic adenocarcinoma cells xenografted into nude mice or cultured in vitro. Nude mice implanted with SWβ1990 tumors received s.c. injections of RCβ3095 and RCβ3940βII or th