Inhibition of glycosylation prevents H-2K and D antigen expression on SV40 virus-transformed cells

✍ Scribed by Sankar Swaminathan; Linda R. Gooding

• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 694 KB
• Volume: 13
• Category: Article
• ISSN: 0014-2980
• DOI: 10.1002/eji.1830130412

✦ Synopsis

H-2K and D antigen expression 335

immune response by a T cell factor [lo] in combination with antigen remains to be clarified.

Macrophages are among the cell types which might be activated by SiOz. However, it is unlikely that this process is a necessary step in the stimulation of cultures by SOz, since in experiments with T cells, adherent cells were strongly depleted. Further support for this view is the finding that Si02 alone had no stimulatory effect under the conditions used.

The results presented in Fig. suggest that Si02 might elicit an enhanced effect by increasing the concentration of the mitogen in situ (see also [ll]). This, however, cannot be the full explanation since Si02 exerted a stimulating effect even at supraoptirnal concentrations of the mitogen (Fig. ).

W e are indebted to Mr. Martin Staub for valuable technical assistance.