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Inhibition of glycogen synthase kinase-3β improves cognitive deficits and tau hyperphosphorylation induced by cerebral ischemia-reperfusion in rats

✍ Scribed by Yao, Xiu-Qing; Zhang, Ya-Ping; Zheng, Jing-Hui

Book ID: 123049101
Publisher: Elsevier Science
Year: 2013
Tongue: English
Weight: 72 KB
Volume: 9
Category: Article
ISSN: 1552-5260
DOI: 10.1016/j.jalz.2013.05.1415

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## Abstract Excitotoxicity and cell death induced by glutamate are involved in many neurodegenerative disorders. We have previously demonstrated that excitotoxicity induced by millimolar concentrations of glutamate in hippocampal slices involves apoptotic features and glutamate‐induced glutamate re