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Inhibition of Glycogen Synthase Kinase-3 in Androgen-Responsive Prostate Cancer Cell Lines: Are GSK Inhibitors Therapeutically Useful?

✍ Scribed by Rinnab, Ludwig (author);Schütz, Stefanie V. (author);Diesch, Jeannine (author);Schmid, Evi (author);Küfer, Rainer (author);Hautmann, Richard E. (author);Spindler, Klaus Dieter (author);Cronauer, Marcus V. (author)

Book ID
122142887
Publisher
Neoplasia
Year
2008
Tongue
English
Weight
630 KB
Volume
10
Category
Article
ISSN
1522-8002

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## Abstract The androgen receptor (AR) is a ligand‐dependent transcription factor belonging to the steroid hormone receptor superfamily. Under normal conditions, in the absence of a ligand, the AR is localized to the cytoplasm and is actively transported into the nucleus upon binding of androgens.