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Inhibition of glutathione reductase by flavonoids: A structure-activity study

✍ Scribed by Andrew J. Elliott; Sandra A. Scheiber; Carin Thomas; Ronald S. Pardini

Book ID
115782921
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
699 KB
Volume
44
Category
Article
ISSN
0006-2952

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In preparations of Wistar rat myocardium, Km values of GSH-Px to the substrates, H2O2 and GSH, as determined by the DTNB method, were 1.9 x 10(-4) mol/L and 2.0 x 10(-3) mol/L respectively. The Km value of GSSG-R to GSSG was 6.0 x 10(-5) mol/L by UV spectrophotometric assay. In vitro, the activity o