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Inhibition of glial cell activation ameliorates the severity of experimental autoimmune encephalomyelitis

✍ Scribed by Xiaoli Guo; Kazuaki Nakamura; Kuniko Kohyama; Chikako Harada; Heather A. Behanna; D. Martin Watterson; Yoh Matsumoto; Takayuki Harada

Book ID
116775948
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
744 KB
Volume
59
Category
Article
ISSN
0168-0102

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## Abstract Agonists of liver X receptors (LXR), members of the nuclear hormone receptor superfamily, alter secretion of proinflammatory cytokines, suggesting potential antiinflammatory effects. A synthetic LXR agonist inhibited T‐cell proliferation and cytokine release in a dose‐dependent manner.