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Inhibition of Gene Expression and Cell Proliferation by Triple Helix-Forming Oligonucleotides Directed to the c-myc Gene †

✍ Scribed by Catapano, Carlo V.; McGuffie, Eileen M.; Pacheco, Daniel; Carbone, Giuseppina M. R.


Book ID
126881559
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
231 KB
Volume
39
Category
Article
ISSN
0006-2960

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The promoter region of the c-fos oncogene 5' flanking sequence contains enhancer elements crucial for binding nuclear factors that regulate transcription following cell proliferation and differentiation. Single-stranded deoxyoligonucleotides were chosen for modulation of c-fos protooncogene expressi