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Inhibition of Fucosyl Transferase and Fucosidase by a Rigid Bicyclic Mimic of α-L-Fucose

✍ Scribed by Annabel R Beacham; Kathryn H Smelt; Keith Biggadike; Christopher J Britten; Lucy Hackett; Bryan G Winchester; Robert J Nash; Rhodri C Griffiths; George W.J Fleet

Book ID
104258445
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
801 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

A rigidbicyclic analogge of a-L-fpcose, prepsred from a monoacetonide of Lgulonolactone in an overatl yield of 36% with6utthe need fti. cohmm chromatography,is a potentinhibitorof fueoaidases~d a weak inhibitorof a fucosyl transferaae. r?) 1997ElwvierScienceLtd. Allrightsresewed.

Analogues of L-fhcoae1 mayinhibitenzymeswhich hydrolyse(fucosida&e)l or make (fucosyl, twnsferases)' oligosaccharides, or may bind to receptorswhich are importantcornpdnentsof cell-cellrecognitionsuch as Lewis X.3Thereare anenormousnumberof potentialapplicatlmgofmaterialsthat havesp=ific intet'=tionsin anyof thesebiological pmcesaes,not onlyas potentiti chemothdqe utic agentsbut more certainlyas probes forthe understandingof a numberof processesin whichthe imndominant sugarL-fucow is involved.'

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