Tumor cells must attach themselves to basement membranes, through which they degrade and migrate, in order to spread to distant sites. If vascular endothelial cells are damaged by pretreatment with anticancer drugs and the subendothelial basement membranes are exposed, the attachment of malignant ce
β¦ LIBER β¦
Inhibition of experimental metastasis of murine fibrosarcoma cells by oligopeptide analogues to the fibronectin cell-binding site
β Scribed by Sergio Bretti; Paolo Neri; Luisa Lozzi; Mauro Rustici; Paolo Comojlio; Filippo Giancotti; Guido Tarone
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- French
- Weight
- 492 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0020-7136
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Skin decorin (DCN) is an antiadhesive dermatan sulfate-rich proteoglycan that interacts with thrombospondin-1 (TSP) and inhibits fibroblast adhesion to TSP [WinnemΓΆller et al., 1992]. Molecular mechanisms by which DCN interacts with TSP and inhibits cell adhesion to TSP are unknown. In the present s