## Abstract The eukaryotic translation initiation factor 5A (eIF5A) contains a special amino acid residue named hypusine that is required for its activity, being produced by a postโtranslational modification using spermidine as substrate. Stem cells from rat skeletal muscles (satellite cells) were
Inhibition of eukaryotic translation initiation factor 5A (eIF5A) hypusination impairs melanoma growth
โ Scribed by Miriam G. Jasiulionis; Augusto D. Luchessi; Andreia G. Moreira; Pedro P. C. Souza; Ana P. M. Suenaga; Mariangela Correa; Carlos A. S. Costa; Rui Curi; Claudio M. Costa-Neto
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 149 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0263-6484
- DOI
- 10.1002/cbf.1351
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## Abstract Eukaryotic translation initiation factor 5A (eIF5A) has a unique character: the presence of an unusual amino acid, hypusine, which is formed by postโtranslational modifications. Even before the identification of hypusination in eIF5A, the correlation between hypusine formation and prote
## Abstract Eukaryotic initiation factor 5A (eIF5A) is the only protein in nature that contains hypusine, an unusual amino acid formed postโtranslationally in two steps by deoxyhypusine synthase and deoxyhypusine hydroxylase. Genes encoding eIF5A or deoxyhypusine synthase are essential for cell sur
Deoxyhypusine synthase catalyzes the conversion of lysine to deoxyhypusine residue on the eukaryotic initiation factor 5A (eIF-5A) precursor using spermidine as the substrate. Subsequent hydroxylation of the deoxyhypusine residue completes hypusine formation on eIF-5A. Hypusine formation is one of t
Eukaryotic initiation factor 5A (eIF-5A) is the only protein in nature that contains hypusine, an unusual amino acid residue formed posttranslationally by deoxyhypusine synthase and deoxyhypusine hydroxylase. Although the eIF-5A gene is essential for cell survival and proliferation, the precise func