Inhibition of epidermal growth factor receptor activation by tyrosine kinase inhibitor enhances in vivo histamine stimulated gastric acid secretion in the rat
โ Scribed by Ancha, Hari B.; Tedesco, Dustin S.; Ancha, Hanumantha R.; Harty, Richard F.
- Book ID
- 122018574
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 263 KB
- Volume
- 124
- Category
- Article
- ISSN
- 0016-5085
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High expression of the epidermal growth factor receptor (EGFR) in breast carcinoma confers a growth advantage to the tumor cells. The EGFR tyrosine kinase inhibitor (EGFR-TKI) ZD1839 ('Iressa') has clinical activity in a wide range of tumor types, although the mechanism(s) by which it exerts its ant