𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Inhibition of eosinophilia in vivo by a small molecule inhibitor of very late antigen (VLA)-4

✍ Scribed by Hiromi Okigami; Keisuke Takeshita; Masaomi Tajimi; Hiroshi Komura; Markus Albers; Thomas E. Lehmann; Thomas Rölle; Kevin B. Bacon

Book ID
113586653
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
501 KB
Volume
559
Category
Article
ISSN
0014-2999

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Physical characterization of TRK-720 hyd
Physical characterization of TRK-720 hydrate, the very late antigen-4 (VLA-4) inhibitor, as a solid form for inhalation: Preparation of the hydrate by solvent exchange among its solvates and mechanistical considerations
✍ Motohiro Shiraki 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 707 KB

TRK-720 has been under development as a dry powder inhaler (DPI) for treating bronchial asthma. DPI is a drug formulation of an active pharmaceutical ingredient (API) supported by carrier particles. On inhalation, the API particles dissociate from the carriers through physical stimulation and reach

Inhibition of Antigen-induced Pulmonary
Inhibition of Antigen-induced Pulmonary Eosinophilia and Neutrophilia by Selective Inhibitors of Phosphodiesterase Types 3 or 4 in Brown Norway Rats
✍ R.E. Howell; L.P. Jenkins; L.E. Fielding; D. Grimes 📂 Article 📅 1995 🏛 Elsevier 🌐 English ⚖ 446 KB

SUMMARY: Rolipram, a phosphodiesterase type 4 (PDE4)-selective inhibitor, has been demonstrated to inhibit antigen-induced pulmonary eosinophilia in guinea pigs and monkeys, suggesting that PDE4-selective inhibitors could be useful for treating asthma. Although the rat is used extensively in preclin