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Inhibition of enzymic reactions by transition state analogs: An approach for drug design

✍ Scribed by Ngo, T.T.; Tunnicliff, G.


Book ID
122831754
Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
652 KB
Volume
12
Category
Article
ISSN
0306-3623

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The relation between the structure of haptens and the esterolytic activities of antibodies was investigated. We synthesized two phenylalanine analogs, the negatively charged phosphonate derivative 1 and the neutral pbosphonamidate derivative 2. Seventeen out of 41 monoelonal antibodies generated ag