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Inhibition of enkephalinase activity attenuates naloxone-precipitated withdrawal symptoms

โœ Scribed by Haffmans, Judith; Dzoljic, Mihailo R.

Book ID
122085363
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
306 KB
Volume
18
Category
Article
ISSN
0306-3623

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Amelioration of naloxone-precipitated op
Amelioration of naloxone-precipitated opioid withdrawal symptoms by peripheral administration of the enkephalinase inhibitor acetorphan
โœ S. J. Livingston; R. D. E. Sewell; K. F. Rooney; H. J. Smith ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› Springer ๐ŸŒ English โš– 477 KB

The effects of 60 min pretreatment with the enkephalinase inhibitor acetorphan were assessed on naloxone-precipitated (2.5 mg/kg IP) abstinence in chronically morphinized rats. In addition, the antinociceptive activity of the compound was investigated in mice. Intraperitoneal injection (50 mg/kg) in