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Inhibition of endothelial cell proliferation by targeting Rac1 GTPase with small interference RNA in tumor cells

✍ Scribed by Yan Xue; Feng Bi; Xueyong Zhang; Yanglin Pan; Na Liu; Yi Zheng; Daiming Fan

Book ID: 116288817
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 460 KB
Volume: 320
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2004.06.088

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## Abstract Rac1 is a Rho subfamily small GTPase which is highly expressed in epidermal keratinocytes. In mice the significance of Rac1 for the maintenance of the epidermis has been controversial. In keratinocytes from human origin, the role of Rac1 in the control of growth/differentiation is still