Inhibition of Endothelial Cell Migration by Gene Transfer of Tissue Inhibitor of Metalloproteinases-1
β Scribed by Harold A. Fernandez; Klaus Kallenbach; Graziano Seghezzi; Eugene Grossi; Stephen Colvin; Robert Schneider; Paolo Mignatti; Aubrey Galloway
- Book ID
- 115635800
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 361 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0022-4804
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Tissue inhibitor of metalfoproteinase-2 (TIMP-2), a protease inhibitor that binds to the latent and active forms of 72 kDa type IV collagenase (gelatinase A), was found to inhibit the in vitro proliferation of human microvascular endothelial (HME) cells stimulated with bFGF and 5% serum. The maximal
Objective. The imbalance between matrix metalloproteinases (MMPs) 1, 3, and 9 and their specific inhibitor, tissue inhibitor of metalloproteinases 1 (TIMP-1), is a critical step in cartilage injury and angiogenesis in arthritis. To explore the therapeutic potential of TIMP-1 gene transfer in erosive