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Inhibition of endoplasmic reticulum associated degradation reduces endoplasmic reticulum stress and alters lysosomal morphology and distribution

✍ Scribed by Elfrink, Hyung Lim; Zwart, Rob; Baas, Frank; Scheper, Wiep


Book ID
120301357
Publisher
Korean Society for Molecular and Cellular Biology
Year
2013
Tongue
English
Weight
502 KB
Volume
35
Category
Article
ISSN
1016-8478

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## Abstract ATF6, a 670 amino acid endoplasmic reticulum (ER) transmembrane glycoprotein with the electrophoretic mobility of a 90 kDa protein, is a key transcriptional activator of the unfolded protein response (UPR) that allows mammalian cells to maintain cellular homeostasis when the cells are s