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Inhibition of eIF4E phosphorylation reduces cell growth and proliferation in primary central nervous system lymphoma cells

✍ Scribed by Daisuke Muta; Keishi Makino; Hideo Nakamura; Shigetoshi Yano; Mareina Kudo; Jun-ichi Kuratsu

Publisher
Springer US
Year
2010
Tongue
English
Weight
582 KB
Volume
101
Category
Article
ISSN
0167-594X

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## Abstract Cerebral hypoxia induces a profound angiogenic response in the central nervous system (CNS). Using a mouse model of chronic cerebral hypoxia, we previously demonstrated that angiogenic vessels in the hypoxic CNS show marked upregulation of the extracellular matrix (ECM) protein fibronec