INHIBITION OF EARLY DNA-DAMAGE AND CHROMOSOMAL ABERRATIONS BY TRIANTHEMA PORTULACASTRUM L. IN CARBON TETRACHLORIDE-INDUCED MOUSE LIVER DAMAGE
✍ Scribed by Alok Sarkar; Soumen Pradhan; Indranil Mukhopadhyay; Subrata K Bose; Shyamal Roy; Malay Chatterjee
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 118 KB
- Volume
- 23
- Category
- Article
- ISSN
- 1065-6995
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✦ Synopsis
The underlying molecular mechanisms of the antihepatotoxic activity of Trianthema portulacastrum by monitoring its effect on mouse liver DNA-chain break, sugar-base damage and chromosomal aberrations, during chronic or acute treatment with carbon tetrachloride (CCl 4 ) have been studied. Daily oral feeding with the ethanolic extract (150 mg/kg basal diet, per os) was given 2 weeks before CCl 4 treatment and continued until the end of the experiment (13 weeks). T. portulacastrum extract offer unique protection (P<0.05-0.001) against the induction of liver-specific structural-type chromosomal anomalies 15, 30 or 45 days after the last CCl 4 insult, compared to control mice. This was further evidenced by extract-mediated protection (15 days prior feeding following a single necrogenic dose of CCl 4 ) of the generation of DNA chain-break and Fe-sugar-base damage assays. The observed hepatoprotective mechanism could be due to its ability to counteract oxidative injury to DNA in the liver of mouse.