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Inhibition of dopamine release by melatonin: regional distribution in the rat brain

✍ Scribed by Nava Zisapel; Yaacov Egozi; Moshe Laudon

Book ID
118867422
Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
238 KB
Volume
246
Category
Article
ISSN
0006-8993

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✦ Synopsis

Dopamine release evoked by electrical field stimulation of slices from various regions of rat brain was assessed in the presence of 10 1Β°-10 , 5 M melatonin. Inhibition of dopamine release by melatonin was observed in the ventral hippocampus, medulla ports, preoptic area and median and posterior hypothalamus. No inhibitory effect of melatonin on dopamine release was observed in the cerebral cortex, cerebellum, dorsal hippocampus and striatum. Equal concentrations of melatonin were needed to produce halfmaximal inhibition in all the regions affected. The results indicate that the brain sites for the inhibitory effect of melatonin on dopamine neurosecretion overlap the sites reportedly involved in its modulation of neuroendocrine functions.

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