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Inhibition of DNA synthesis in P388 lymphocytic leukemia cells of BDF1 mice by cis-Diamminedichloroplatinum(II) and its derivatives

✍ Scribed by C. Brent Oswald; Stephen G. Chaney; Iris H. Hall


Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
643 KB
Volume
79
Category
Article
ISSN
0022-3549

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The combination of cis-diamminedichloroplatinum(ll) (CDDP) and 7-ethyl-I0-[4-( I -pipmidino)-I -piperidino]carbonyloxycamptothecin (CPT-I I), a topoisomerase-I inhibitor, has been shown to be synergistic in vitro and clinically active against several human cancers refractory to chemotherapy. To eluc