Inhibition of dmba-induced mammary tumorigenesis by caloric restriction in rats fed high-fat diets
✍ Scribed by David M. Klurfeld; Carrie B. Welch; Lisa M. Lloyd; David Kritchevsky
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- French
- Weight
- 414 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Most previous studies on the inhibiting effect of ciiloric restriction during promotion of DMBA-induced mammary carcinogenesis have used low to moderate levels of dietary fat, i.e., about 4 to 14% by weight. The current study was designed to test whether a moderate degree of caloric restriction, 25%, would inhibit tumor growth in rats fed the equivalent of 20% dietary fat which approximates human consumption in affluent countries, Rats were fed diets ad libitum that contained 5, I 5 or 20% corn oil. Groups of cats were pair-fed to the last 2 groups, but subjected to a 2554 caloric restriction. These groups were fed 20 or 26.7% corn ail so that absolute fat intake in the paired groups was identical. Significant inhibition of tumor incidence, tumor weight, tuimor burden, body fat deposition, and fasting serum insulin were observed in the 2 calorically restricted groups. We concllude that moderate caloric restriction is significantly more effective in inhibiting tumor growth than is the promoting effect of diets high in fat. Total body weight, body fat and serurn insulin concentrations may be better correlates of risk of developing mammary tumors than is dietary fat.