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Inhibition of deoxyribonucleic acid chain initiation: a new mode of action for 1-β-D-arabinofuranosylcytosine in human lymphoblasts

✍ Scribed by Fridland, Arnold


Book ID
126115473
Publisher
American Chemical Society
Year
1977
Tongue
English
Weight
601 KB
Volume
16
Category
Article
ISSN
0006-2960

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Mode of action of 1-β-D-arabinofuranosyl
✍ Fridland, Arnold 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 English ⚖ 592 KB

This paper describes a novel biochemical effect of 1 -P-D-arabinofuranosylcytosine (Ara-C), a potent antitumor agent, on the process of DNA replication in cultures of human lymphoblasts (CCRF-CEM). By using short incubation periods of five minutes with 3H-thymidine and analyzing the nascent DNA by v