Mode of action of 1-β-D-arabinofuranosyl
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Fridland, Arnold
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Article
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1982
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John Wiley and Sons
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English
⚖ 592 KB
This paper describes a novel biochemical effect of 1 -P-D-arabinofuranosylcytosine (Ara-C), a potent antitumor agent, on the process of DNA replication in cultures of human lymphoblasts (CCRF-CEM). By using short incubation periods of five minutes with 3H-thymidine and analyzing the nascent DNA by v