Inhibition of dendritic cell maturation by herpes simplex virus

✍ Scribed by Mariolina Salio; Marina Cella; Mark Suter; Antonio Lanzavecchia

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 322 KB
• Volume: 29
• Category: Article
• ISSN: 0014-2980
• DOI: 10.1002/(sici)1521-4141(199910)29:10<3245::aid-immu3245>3.0.co;2-x

✦ Synopsis

Maturation of dendritic cells (DC), leading to migration and increased T cell stimulatory capacity, is essential for the initiation of immune responses. This process is triggered by a variety of stimuli, such as inflammatory cytokines, bacterial and viral products. Using a recombinant disabled infectious single cycle herpes simplex virus 1 (HSV-1) encoding green fluorescent protein, we show that the infected DC are defective in up-regulating costimulatory molecules, do not produce cytokines, and do not acquire responsiveness to chemokines required for migration to secondary lymphoid organs. These results reveal yet another strategy used by HSV-1 to evade the immune response, namely the inhibition of signaling pathways involved in DC maturation.