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Inhibition of D-amino Acid Oxidase by α-Keto-γ-Methiolbutyric Acid, product of the reaction with D-Methionine

✍ Scribed by J. A. Moreno; J. Catalán; M. A. Galán

Publisher
Springer Netherlands
Year
1994
Tongue
English
Weight
281 KB
Volume
16
Category
Article
ISSN
0141-5492

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✦ Synopsis

The inhibition of D-Amino Acid Oxidase by a-Keto Acid, product of the reaction with D-Amino Acid is described for the first time. Inhibition of the enzyme by o-Ketoy-Methiolbutyric Acid (4-methylthio-2-oxobutanoic acid), product of the reaction with D-Methionine, was studied. From the results obtained it is deduced that inhibition is competitive with the substrate, the value of the inhibition constant being 1.85 1 O-? M.

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