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Inhibition of cytosolic phospholipase A2 mRNA expression: a novel mechanism for acetylsalicylic acid-mediated growth inhibition and apoptosis in colon cancer cells

✍ Scribed by Hong-Gang Yu; Jie-An Huang; Yan-Ning Yang; He-Sheng Luo; Jie-Ping Yu; Juris J. Meier; Henning Schrader; Andreas Bastian; Wolfgang E. Schmidt; Frank Schmitz

Book ID: 117349030
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 237 KB
Volume: 114
Category: Article
ISSN: 0167-0115
DOI: 10.1016/s0167-0115(03)00084-3

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## Abstract Her‐2/__neu__ (__erb__B‐2) oncogene overexpression is associated with increased tumor progression and metastasis. Fatty acid synthase (FAS), the key lipogenic enzyme responsible for the endogenous synthesis of fatty acids, has been shown to be one of the genes regulated by Her‐2/__neu__