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Inhibition of cytochrome P450 isozymes by curcumins in vitro and in vivo

✍ Scribed by R Thapliyal; G.B Maru


Book ID
117449728
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
252 KB
Volume
39
Category
Article
ISSN
0278-6915

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Zafirlukast is a cysteinyl leukotriene antagonist used to treat allergic and exercise-induced asthma. This in vitro study used human liver microsomes to evaluate the inhibitory activity of zafirlukast versus six human cytochrome P450 (CYP) isoforms. Zafirlukast (0 -250 mM) was co-incubated with fixe