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Inhibition of crystal nucleation and growth by water-soluble polymers and its impact on the supersaturation profiles of amorphous drugs

✍ Scribed by Ozaki, Shunsuke (author);Kushida, Ikuo (author);Yamashita, Taro (author);Hasebe, Takashi (author);Shirai, Osamu (author);Kano, Kenji (author)

Book ID: 120507995
Publisher: John Wiley and Sons Inc.
Year: 2013
Tongue: English
Weight: 452 KB
Volume: 102
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.23588

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In order to better understand the oral absorption behavior of poorly water-soluble drugs, their supersaturation-nucleation behavior was characterized in fasted state simulated intestinal fluid. The induction time (t ind ) for nucleation was measured for four model drugs: itraconazole, erlotinib, tro