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Inhibition of costimulatory pathways for T-cell activation by 1,25-dihydroxyvitamin D3

✍ Scribed by G Penna; L Adorini


Book ID
117230914
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
217 KB
Volume
33
Category
Article
ISSN
0041-1345

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To characterize the mechanism(s) by which 1,25dihydroxyvitamin D, (calcitriol) modulates the costimulatory capacity of monocytes, we examined the effect of calcitriol pretreatment of monocytes on their capacity to promote T cell proliferation (accessory cell function). Correlation of calcitriol-depe