Inhibition of constitutive NFκB activity by the anti-inflammatory sesquiterpene, parthenolide slows cell growth and increases radiation sensitivity

Sesquiterpene lactone parthenolide suppr

Sesquiterpene lactone parthenolide suppresses tumor growth in a xenograft model of renal cell carcinoma by inhibiting the activation of NF-κB

✍ Daizo Oka; Kazuo Nishimura; Masahiro Shiba; Yasutomo Nakai; Yasuyuki Arai; Masas 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 459 KB

## Abstract The transcription factor nuclear factor‐κB (NF‐κB) has been shown to be constitutively activated in various human malignancies, including leukemia, lymphoma and a number of solid tumors. NF‐κB regulates the transcriptional of genes important for tumor invasion, metastasis and chemoresis