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Inhibition of Collagenase Activity by N-Chlorotaurine, a Product of Activated Neutrophils

✍ Scribed by Joanna M. S. Davies; David A. Horwitz; Kelvin J. A. Davies

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 340 KB
Volume: 37
Category: Article
ISSN: 0004-3591
DOI: 10.1002/art.1780370317

No coin nor oath required. For personal study only.

✦ Synopsis

To study the effects of N-chlorotaurine on collagenase activity, as a model of the effects of neutrophil activation in inflammatory arthritis.

Methods. Collagen degradation by collagenase was measured by the release of acid-soluble counts from 3H-collagen.

Results. N-chlorotaurine inhibited the degradation of collagen by bacterial collagenase. This result is explained by a direct inhibitiodinactivation of collagenase, since N-chlorotaurine had no effect on the proteolytic susceptibility of collagen itself. The effect appears to be specific to N-chlorotaurine since N-chloroalanine, N-chloroleucine, and HOCVOCI-failed to inhibit colagenase; in fact, N-chloroalanine and N-chloroleucine actually increased the proteolytic susceptibility of collagen.

Conclusion. N-chlorotaurine may minimize damage to cartilaginous joht structures in inflammatory arthritis by inhibitingjinactivating collagenase.

Polymorphonuclear leukocytes (PMN) are found in high concentrations in the synovial fluid of patients with inflammatory arthritis. Activated PMN

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