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Inhibition of cholesterol side chain cleavage by cyanoketone (2α-cyano-4,4,17α-trimethyl-17β-hydroxyandrost-5-en-3-one)

✍ Scribed by Robert V. Farese


Book ID
119481113
Publisher
Elsevier Science
Year
1970
Tongue
English
Weight
222 KB
Volume
15
Category
Article
ISSN
0039-128X

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Catalytic reduction of 3β-hydroxyandrost
✍ Yusuf J. Abul-Hajj 📂 Article 📅 1971 🏛 John Wiley and Sons 🌐 French ⚖ 349 KB

Catalytic reduction of 3j3-hydroxyandrost-4-ene-l7-one (I) with tritium gas gave a mixture of 3B-hydroxy-5a-androstane-17-one (11) and 3~-hydroxy-5cc-androstane-l7-one ( 1 1 1 ) . Oxidation of compound 1 1 followed by alkaline equilibration resulted in 37 % loss of label from position 4. 5a-Androsta