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Inhibition of Cell Proliferation and AP-1 Activity by Acrolein in Human A549 Lung Adenocarcinoma Cells Due to Thiol Imbalance and Covalent Modifications

โœ Scribed by Biswal, Shyam; Acquaah-Mensah, George; Datta, Kaushik; Wu, Xuli; Kehrer, James P.


Book ID
126092120
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
128 KB
Volume
15
Category
Article
ISSN
0893-228X

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## Abstract The type 1 insulin-like growth factor receptor (IGF-1R), which is over-expressed or activated in many human cancers, including lung cancer, mediates cancer cell proliferation and metastasis. Several studies indicate that blocking IGF-1R expression can inhibit tumor cell proliferation an