Inhibition of cell growth of human hepatoma cell line (HEP G2) by a farnesyltransferase inhibitor: A selective suppression of RAS farnesylation 2nd Dept. of Int. Med., Osaka University Med. School, Osaka, Japan

Inhibition of cell growth of human hepat

Inhibition of cell growth of human hepatoma cell line (HepG2) by a farnesyl protein transferase inhibitor: A preferential suppression of ras farnesylation

✍ Toshihiko Nagase; Sumio Kawata; Shinji Tamura; Yukihiko Matsuda; Yoshiaki Inui; 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 776 KB

So far, treatment with anti-cancer agents has failed to achieve satisfactory results in hepatocellular carcinoma. In the process of hepatocarcinogenesis, ras has been shown to play a role. ras requires a farnesyl moiety for activation. It has been found that UCF I -C (manumycin). an antibiotic, inhi